mTOR Signaling in Kidney Diseases
نویسندگان
چکیده
منابع مشابه
Overnutrition, mTOR signaling, and cardiovascular diseases.
The prevalence of obesity and associated medical disorders has increased dramatically in the United States and throughout much of the world in the past decade. Obesity, induced by excess intake of carbohydrates and fats, is a major cause of Type 2 diabetes, hypertension, and the cardiorenal metabolic syndrome. There is emerging evidence that excessive nutrient intake promotes signaling through ...
متن کاملP162: Emerging Perspectives on Mtor-Associated Inflammation in Neurodegenerative Diseases
Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...
متن کاملmTOR Signaling.
The scarcity of nutrients/energy interspersed with sporadic periods of abundance means that cells must transition between anabolic and catabolic states. An important protein that has evolved to respond to this need is the target of rapamycin (TOR). TOR is a well-conserved serine/ threonine kinase that plays an important role in the signaling network that controls growth and metabolism in respon...
متن کاملmTOR signaling in protein homeostasis
Protein homeostasis—a delicate equilibrium between synthesizing proteins, maintaining protein conformations, refolding misfolding proteins and removing damaged proteins—is normally maintained by cellular networks involving ribosomes, chaperones and the ubiquitin-proteasome system. Ribosomes decode genetic information and convert it into the amino acid sequences of proteins. Molecular chaperones...
متن کاملProspects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases.
Mammalian target of rapamycin (mTOR) is the core component of two complexes, mTORC1 and mTORC2. mTORC1 is inhibited by rapamycin and analogues. mTORC2 is impeded only in some cell types by prolonged exposure to these compounds. mTOR activation is linked to tubular cell proliferation in animal models and human autosomal dominant polycystic kidney disease (ADPKD). mTOR inhibitors impede cell prol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney360
سال: 2020
ISSN: 2641-7650
DOI: 10.34067/kid.0003782020